Name 

= 

Described 

Clinical 

Site 

Prognosis 

Rx 

Merkel cell carcinoma

Trabecular ca

1972

Painless, dome shaped, pink –purple nodule

H & N
Sun exposed sites

Extremely dangerous ca

2-3 cm WLE +/- radio +/- chemo

Atypical Fibroxanthoma

AFX

1963

Ulcerated lesion

H & N (men)

Relatively benign – 10% mets

WLE,
Mohs

Malignant Fibrous Histiocytoma

MFH

1960s

Deep smooth tumour

5 yr survival = 60%

WLE. Mohs

Dermatofibrosarcoma Protruberans

DFSP

1920

1-3 per million population
slow growing firm multinodular plaque

Extensive subclinical extension

5cm margins = 20% RR, Mohs <5%

Mohs, gleevac for inoperable dfsp

Extra-Mammary Pagets Disease

EMPD

1889

Rare, may be ssoc c underling adenocarcinoma

Reddish, eroded patch, anogenital skin

RR = 33% with surgery, 23% after Mohs

Mohs, WLE

Angiosarcoma

1945

<1/1000 H&N ca

Bruised like red purple plaque nodules

5yr =10-20%

WLE + radio

Sebaceous carcinoma

1880

Periocular firm nodules on inner surface of eyelids [75% on eyelids]

Eyelids 75%

May be multifocal

Mohs

Leiomyosarcoma

Skin sites mean a less aggressive cancer than other body sites

WLE, Mohs

Eccrine porocarcinoma

Sarcomatoid carcinoma

Mucinous carcinoma [from ref 1]

1952

Clusters of basaloid cells with a cribriform pattern surrounded by clear pools of loosely woven mucinous stroma. +ve for cytokeratin. mucin=alcian blue
slow growing solitary sweat gland neoplasm of eccrine secretory coil, average age=63

Eyelid 40%, face, scalp

Up to 43% RR

Mohs, WLE

Microcystic adnexal carcinoma

Sclerosing sweat duct carcinoma

1982

Aggressive, locally destructive, extensive subclinical extension

Slow growing yellowish plaque central face eg lip

Perineural inv 80%

Mohs

Trcihoblastoma